Study on the Functional Characterization of 9‑epi-Caryophyllene Synthase from <i>Lavandula x intermedia</i> (Lavandin).

ABSTRACT: Lavender species hold considerable economic importance and are widely grown across the globe for their essential oils (EOs), which are rich in terpenes vital for the cosmetic, personal care, and pharmaceutical sectors. EOs consist mainly of monoterpenes, though certain species may also include small quantities of sesquiterpenes, depending on genetic and environmental factors. The sesquiterpene 9-epi-caryophyllene, produced by Lavandula x intermedia 9-epi-caryophyllene synthase (LiCPS), constitutes up to 8% of lavender EOs. However, the mechanistic basis of LiCPS activity is still unclear. Herein, we determined the hydrodynamic radius of LiCPS to be 5.7 ± 0.2 nm. Molecular docking simulations were conducted using a structural model predicted using AlphaFold2, followed by site-specifi

SUBMITTER: Liu D 

PROVIDER: S-EPMC12423831 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature