<i>Sapindus mukorossi</i> as a Bioenhancer for the Biocidal Action of Polymyxin B.

ABSTRACT: Bacterial infections remain a significant health concern, necessitating the continuous exploration of novel therapeutic strategies. Sapindus mukorossi extract, renowned for its bioactive saponins, presents a promising approach for combating bacterial pathogens. This study investigates the potential of S. mukorossi extract (SM) as a bioenhancer for the polymyxin B antibiotic (PMB) against four bacterial strains: Staphylococcus aureus (SA), Staphylococcus epidermidis (SE), Pseudomonas aeruginosa (PA), and Escherichia coli (EC). Research methods were used to determine the metabolic activity of the strains and the changes in their cell membrane permeability. Furthermore, advanced microscopic techniques (confocal and transmission electron microscopy) we

SUBMITTER: Makiej A 

PROVIDER: S-EPMC12423858 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature