Biological Merits and Antibiofilm Mechanisms of Action of a Specially Designed Double-Shelled Microparticle.

ABSTRACT: We recently fabricated a double-shelled microparticle (DSMP) incorporating a quaternary ammonium compound (QAC) and quinine, which demonstrated promising anti-infective properties. In this study, we aimed to elucidate biological merits and antibiofilm mechanisms of action of the specifically designed DSMP. Antimicrobial activities of the DSMP against 32 Gram-positive clinical isolates and laboratory strains were assessed by determining the minimum inhibitory concentrations (MICs). Antibiofilm efficacies of the DSMP were evaluated by using a tetrazolium salt reduction assay and confocal laser scanning microscopy. The fractional inhibitory concentration index was determined to clarify drug-drug interactions between QAC and quinine. Evolution of DSMP resistance was experimentally assessed by

SUBMITTER: Sheng C 

PROVIDER: S-EPMC12423863 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature