Structural Characterizations and In Vitro Bioactivities of a d‑Fructose-Rich Polysaccharide from <i>Gymnopetalum cochinchinense</i> as a Potential Candidate for Alleviating Alzheimer's Disease.

ABSTRACT: The presented investigation attempts to unveil the structural characteristics, bioactivities, and potential application of Gymnopetalum cochinchinense-derived d-fructose-rich heteropolysaccharide (denoted as PS-HB5) for the treatment of Alzheimer's disease (AD). Structural analyses of the PS-HB5 evaluated by FT-IR, GC-MS, and NMR techniques reveal a novel repeating unit composed of d-glucose and d-fructose linked through (1 → 6)-glucosyl, (2 → 6)-fructosyl, and (2 → 4)-fructosyl bonds, and possesses a molecular weight of 1.217 × 10⁵ Da. The PS-HB5 exhibits strong antioxidant activity, as evidenced by its DPPH and ABTS radical scavenging rates of 84.12% and 74.14%, associated with the IC₅₀ values of 0.80 and 3.06 mg.mL^-1, respectively. In addition, th

SUBMITTER: Van DTT 

PROVIDER: S-EPMC12423878 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature