<i>In Situ</i> Homogeneous Generation of Copper Nanoparticles in Collagen-Cellulose Freeze-Dried Foams Using Natural Reduction Agents to Enhance Their Stability, Antibacterial Properties, and Cytocompatibility.

ABSTRACT: The treatment of chronic wounds remains a major challenge in regenerative medicine due to prolonged healing times, susceptibility to infection, and underlying conditions like diabetes. Incorporating bioactive and antibacterial nanoparticles (NPs) into wound dressings can significantly enhance their mechanical properties, structural integrity, and functionality, improving stability, biocompatibility, and healing efficacy. However, conventional methods of loading NPs in polymer matrices often lead to uneven distribution and localized toxicity. To overcome these limitations, we employ a novel in situ synthesis of copper nanoparticles (CuNPs) using an encapsulation method via the self-assembled polymerization of dopamine (DOPA) or tannic acid (TA) within collagen/carboxymethyl cellulose

SUBMITTER: Polakova V 

PROVIDER: S-EPMC12423890 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature