Bimetallic Cu/Zn Single-Atom Nanozyme with Superoxide Dismutase-Like Activity.

ABSTRACT: The superoxide ion (O^2•-), a radical species, is significant in chemical and biological systems. Nanozymes, enzyme-mimicking nanomaterials, have been developed to replicate superoxide dismutase (SOD), which counters O^2•-. Traditionally, nano ceria (CeO₂) is used for SOD mimicry due to its Ce³⁺/Ce⁴⁺ cycling ability, but issues like toxicity, biodistribution, aggregation, and specificity hinder practical use. Single-atom nanozymes (SANs) offer a solution, with metal centers mimicking natural metal-based enzymes. A Cu/Zn bimetallic SAN is synthesized, structurally resembling natural SOD and exhibiting comparable activity. Its performance is assessed by capturing superoxide radicals and inhibiting Nitro-blue tetrazolium (NBT) photoreductio

SUBMITTER: Hamed EM 

PROVIDER: S-EPMC12423899 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature