Nose-to-Brain Delivery of Acyl-Ghrelin Peptide Gold Nanoconjugates for Treatment of Neurodegenerative Diseases.

ABSTRACT: Neurodegenerative diseases remain a major therapeutic challenge in aging populations. Acyl-ghrelin, a 28-amino acid gut hormone, demonstrates neuroprotective effects but is limited by instability, rapid clearance, and non-specific distribution when systemically delivered. Nose-to-brain delivery using nanotechnology offers a promising alternative. Gold nanorods (AuNRs), with high therapeutics loading capacity, are proposed as carriers for intranasal acyl-ghrelin delivery. The previous study demonstrates that intranasal AuNRs effectively reach the brain with minimal systemic exposure. This work investigates the feasibility of using acyl-ghrelin gold nanoconjugates to deliver and retain its pharmacological activity through intranasal administration for neurodegenerative diseases. Acyl-ghrelin

SUBMITTER: Han S 

PROVIDER: S-EPMC12423900 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature