Bioactive Polysulfate-Based Nano-Assemblies Against Virus Infection.

ABSTRACT: 3D nanosystems equipped with polysulfates as binding sites are effective virus inhibitors due to their ability to dynamically deform while adhering to a virus. Here, a new supramolecular nanosystem assembled from a block copolymer consisting of sulfated linear polyglycerol and polytrimethylene carbonate is presented. It exhibits a unique morphology, 100 nm sized spheres with a distinct brush-like corona. The negatively charged sulfates are distributed on the outer shell and enable exceptional homogeneity of the particles, thereby enhancing the efficiency of multivalent interactions. Various sulfation levels are tested and demonstrated extremely low half-maximal inhibition concentration (IC₅₀) values in plaque reduction assays tested on herpes simplex virus type-1 (HSV-1): 0.43,

SUBMITTER: Ma G 

PROVIDER: S-EPMC12423918 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature