Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach.

ABSTRACT:

Introduction

This study aimed to identify specific biological pathways and molecules involved in Alzheimer's disease (AD) neuropathology.

Methods

We conducted cutting-edge high-resolution metabolomics profiling of 162 human frontal cortex samples from the Emory Alzheimer's Disease Research Center (ADRC) brain bank with comprehensive neuropathological evaluations.

Results

We identified 155 unique metabolic features and 36 pathways associated with three well-established AD neuropathology markers. Of these, 18 novel metabolites were confirmed with level 1 evidence, implicating their involvement in amino acid metabolism, lipid metabolism, carbohydrate metabolism, nucleotide metabolism, and metabolism of cofactors and vitamins in AD neuropathology. Genetic variability infl

SUBMITTER: Huls A 

PROVIDER: S-EPMC12423944 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature