Longitudinal analysis of serum alpha-fetoprotein in stable and progressive metastatic pancreatic neuroendocrine tumours.

ABSTRACT:

Background

Neuroendocrine tumours (NETs) are a heterogeneous group of rare neoplasms arising from neuroendocrine cells, most commonly found in the gastrointestinal tract and pancreas. Despite novel diagnostic techniques, identifying reliable biomarkers for NETs still remains a challenge.

Objectives

Our study explores the diagnostic, monitoring and prognostic value of alpha-fetoprotein (AFP) in pancreatic NETs.

Materials and methods

We recruited 41 adult patients diagnosed with liver metastatic non-functioning pancreatic NETs. Serum AFP levels were assessed at three-month intervals over a span of four years. For comparative purposes, we analysed data in relation to sex, age, liver tumour burden (LTB; <10%, 10-25%), tumour grade based on the WHO 2022 classification (G1,

SUBMITTER: Musialkiewicz J 

PROVIDER: S-EPMC12424037 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature