Associations of Genetic Variations in the NR3C2 With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incidence of Hypertension in Chinese Adults.

ABSTRACT: Nuclear receptor subfamily 3 group C member 2 (NR3C2) encodes the mineralocorticoid receptor (MR), which plays a pivotal role in the regulation of electrolyte and fluid homeostasis by mediating the physiological actions of mineralocorticoids, primarily aldosterone. In this study, we analyzed data from the Baoji Salt-Sensitivity Study, a population-based dietary intervention conducted in 2004 in northern China. A total of 514 adults from 124 families were enrolled and underwent a controlled salt intake protocol consisting of a 3-day baseline diet, followed by sequential 7-day low-salt (3.0 g/day) and high-salt (18.0 g/day) phases. Participants were prospectively followed for 14 years to evaluate the long-term incidence of hypertension. Our results demonstrated a significant negative associa

SUBMITTER: Wang L 

PROVIDER: S-EPMC12424066 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature