Estimating the Effects of Continuous Albuterol Dosage on Clinical Outcomes for Pediatric Critical Asthma Exacerbation: A Retrospective Cohort Study.

ABSTRACT:

Introduction

Pediatric asthma exacerbations sometimes require aggressive intervention including continuous albuterol, a cornerstone therapy for reversing airway obstruction. However, pediatric dosing typically follows adult guidelines, with limited evidence for specific dosing ranges. This study aimed to compare the clinical outcomes of a reduced initial dose (10 mg/h) of continuous albuterol with a standard dose (15 mg/h) in children hospitalized for critical asthma exacerbations.

Methods

This retrospective cohort study was conducted at Riley Hospital for Children, analyzing pediatric patients (ages: 2-18) admitted with critical asthma exacerbations between 2014 and 2022. Stabilized inverse probability weighting (SIPW) was used to adjust for confounding factors between grou

SUBMITTER: Riggins DP 

PROVIDER: S-EPMC12424099 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature