A United States study of self-collected urine vs clinician-collected cervical sample for HPV and cervical intraepithelial neoplasia grade two or worse detection: Cross-sectional agreement and diagnostic accuracy study.

ABSTRACT:

Objectives

Urine can provide a non-invasive screening method for high-risk human papillomavirus (hrHPV) infections. We aimed to compare detection rates of hrHPV and cervical intraepithelial neoplasia grade two or worse (CIN2+) using first-void urine (FVU) and clinician-collected cervical samples. We assessed whether the time of day of FVU collection impacts hrHPV detection.

Methods

We recruited 188 participants, 30-65 years, before their colposcopy or routine screening from September 2020 through February 2022. Each collected FVU twice on the same day: at home and in the clinic before their appointments. We used prevalence-adjusted bias-adjusted kappa (PABAK) scores to compare hrHPV type-specific agreement, followed by McNemar's Exact test. We assessed both absolute and rela

SUBMITTER: Young AP 

PROVIDER: S-EPMC12424416 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature