Natriuretic Peptide Cut Points for Heart Failure Classification in Individuals With and Without Obesity.

ABSTRACT:

Background

The 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America guidelines introduced elevated natriuretic peptide (NP) levels as a criterion for defining stage B heart failure (HF), or pre-HF, to identify individuals at greatest risk for future HF. Given the known NP deficiency in obesity, we aimed to assess whether a single NP cut point would disproportionately up-classify individuals with versus without obesity to stage B HF.

Methods

Participants free of HF from 5 community-based cohorts were included. We examined the reclassification of individuals to stage B HF using the 2022 versus 2013 guidelines, stratified by obesity class. Cox proportional hazards models were used to assess the association of NPs with incident HF acros

SUBMITTER: Chitsazan M 

PROVIDER: S-EPMC12424528 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature