Enhancing experience-dependent plasticity accelerates vision loss in a murine model of retinitis pigmentosa.

ABSTRACT: Modulating neural plasticity is pursued as a therapeutic approach for several neurologic conditions. Here we evaluated if enhancing experience-dependent plasticity prolongs vision in a murine model of retinitis pigmentosa. First, we quantified the loss of visual acuity under both scotopic and photopic conditions for mice heterozygous for the P23H mutation in the Rhodopsin gene (Rho P23H/+). Acuity progressively declined under scotopic conditions followed by photopic conditions. Acuity deficits only broadly correlated with the retinal response measured by the electroretinogram. In contrast, acuity deficits were consistent with the percent of cortical excitatory layer 2/3 neurons responsive to higher spatial frequency visual stimuli. Then, we tested if enhancing plasticity in a

SUBMITTER: Attaway CA 

PROVIDER: S-EPMC12424633 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature