Neuron type-specific mRNA translation programs provide a gateway for memory consolidation.

ABSTRACT: Long-term memory consolidation is a dynamic process that requires a heterogeneous ensemble of neurons, each with a highly specialized molecular signature. Considerable effort has been devoted to identifying molecular changes that accompany the process of consolidation, but mostly hours or days after training, when memory consolidation is already complete. Studies have shown that protein synthesis is elevated during the early stages of consolidation, but how this increase impacts neuronal function remains unclear. We hypothesize that mRNAs translated during the early stages of consolidation could provide information on how diverse neurons involved in memory formation restructure their molecular signatures to support memory. Here, we generate a landscape of the translatome of three neuron ty

SUBMITTER: Oliveira MM 

PROVIDER: S-EPMC12424637 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature