IRF8 deficiency causes anxiety-like behavior in a sex-dependent manner.

ABSTRACT: Anxiety disorder is a serious psychiatric disease that affects women twice more than men and disrupts patients' daily lives. It is often comorbid with major depression and other mental diseases. Various underlying mechanisms have been proposed, such as neurotransmitters and neuroanatomical disruptions, and more recently, oxidative stress; however, much remained unclear, including the role of glial cells. Here, we investigated the role of IRF8 in anxiety disorders in the mouse model. IRF8 is a transcription factor expressed primarily in microglia in the brain. A battery of behavioral tests revealed that female IRF8 knockout (IRF8KO) mice show increased anxiety relative to male IRF8KO and wild-type mice. Female IRF8KO mice also exhibited a higher tendency for obsessive-compulsive disorder. H

SUBMITTER: Zhu S 

PROVIDER: S-EPMC12424652 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature