CD11c+ Tbet+ B cells constrain obesity- and vaccination-induced germinal center B cells and T helper cells.

ABSTRACT: Obesity is a rapidly growing public health crisis associated simultaneously with increased metabolic disease and humoral immune suppression to vaccination or infection. Inflammatory CD11c+T-bet+ B cells (ABCs) increase in spleen and adipose tissue during obesity and exacerbate metabolic dysfunction via antibodies. We now find that during obesity Tbet+ B cells also expand in the liver but not omentum or mesenteric fat. Obese mice also develop increased splenic CXCR5+ T _FH and hepatic CXCR5-T _PH cells which serve as likely partners for antigen-experienced MHC-II+ ABCs. We also observed that antibodies in obese mice, previously found to contribute to metabolic disease, largely circulate as inflammatory autoantigen-bound immune complexes. Perhaps most striking was our obs

SUBMITTER: Vanz C 

PROVIDER: S-EPMC12424663 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature