SoxB1-Mediated Chromatin Remodeling Promotes Sensory Neuron Differentiation in Planarians.

ABSTRACT: Understanding how adult stem cells generate neurons is critical for advancing regenerative medicine. However, few in vivo models enable studying how stem cell fates are specified as neurons in an adult body. The planarian Schmidtea mediterranea provides a powerful system for investigating these mechanisms, owing to its abundant adult pluripotent stem cells, termed neoblasts, and its capacity to regenerate a molecularly complex nervous system. The SoxB1 family of transcription factors is broadly implicated in ectodermal lineage commitment. In planarians, the SoxB1 homolog soxB1-2 has been shown to promote neural and epidermal differentiation. However, the mechanisms by which soxB1-2 influences chromatin dynamics and transcriptional programs during adult neurogenesis rem

SUBMITTER: Cathell ML 

PROVIDER: S-EPMC12424676 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature