Unique and conserved endoplasmic reticulum stress responses in neuroendocrine cells.

ABSTRACT: Endocrine cells are dedicated to the production and processing of hormones, from peptides to small molecules, to regulate key physiological processes, including glucose homeostasis and metabolism. Because of this relatively high productivity, endocrine cells must handle a variety of stresses from oxidative stress to the unfolded protein response of the endoplasmic reticulum (UPR^ER). While much is known about the major pathways regulating the UPR^ER, the roles of endocrine cell type-specific, context-dependent, and time-dependent transcriptional changes are not well explored. To identify unique and shared responses to the UPR^ER across a subset of endocrine cell types, we tested representative lines for β-cells (insulin), α-cells (glucagon), δ-cells (so

SUBMITTER: Rodrigues-Dos-Santos K 

PROVIDER: S-EPMC12424717 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature