Regulatory logic of neuronal identity specification in <i>Drosophila</i>.

ABSTRACT: During neurogenesis, signaling molecules and transcription factors (TFs) pattern neural progenitors across space and time to generate the numerous cell types that constitute neural circuits. In postmitotic neurons, these identities are established and maintained by another class of TFs known as terminal selectors (tsTFs). However, it remains largely unclear how the tsTF combinations are specified in newborn neurons, and how they then coordinate the type-specific differentiation programs of each neuron. To investigate these regulatory mechanisms, we performed simultaneous single-cell RNA and ATAC sequencing experiments on the Drosophila optic lobes and identified over 250 distinct cell types at four stages of their development. We characterized the common cis-regulatory features of n

SUBMITTER: Coyne R 

PROVIDER: S-EPMC12424757 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature