A New Type of Nonsuppressible Viremia Produced by HIV-Infected Macrophage.

ABSTRACT:

Background

HIV-1 RNA typically declines rapidly after initiation of antiretroviral therapy (ART); often reaching undetectable levels within a few weeks and remaining undetectable by standard assays. However, some patients on ART have persistent nonsuppressible viremia (NSV) that does not respond to treatment optimization or intensification. NSV can emerge at the time of ART initiation (primary NSV) or after being ART-suppressed (secondary NSV). Here, we examine mechanisms producing primary NSV in four people on ART.

Methods

Blood samples were collected from four participants who, despite being adherent to ART, required approximately a year or more to become virologically suppressed. Viral RNA and proviral DNA genomes were sequenced to examine HIV-1 drug

SUBMITTER: Moeser MJ 

PROVIDER: S-EPMC12424842 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature