Longitudinal Multi-Organ Transcriptomic Atlas of Salt-Induced Hypertension.

ABSTRACT:

Background

Salt-sensitive hypertension is a prevalent and clinically significant subtype of hypertension, where increased dietary salt intake elevates blood pressure and causes injury to multiple organ systems. Despite extensive research, dynamic molecular changes and conserved versus organ-specific transcriptional programs in hypertensive multi-organ damage remain poorly understood. Defining complex molecular pathways both in a temporal sequence and in an organ-specific manner is essential for developing targeted, precision therapies to mitigate hypertensive disease burden.

Methods

We generated a longitudinal multi-organ transcriptomic atlas of salt-sensitive hypertension using RNA sequencing of kidney cortex, kidney medulla, heart, and liver from Dahl salt-sensitive rats a

SUBMITTER: Tiwari R 

PROVIDER: S-EPMC12424854 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature