Lifetime risk of incident dementia and incident mild cognitive impairment in older adults.

ABSTRACT:

Background and objectives

To estimate the lifetime risk of dementia and mild cognitive impairment (MCI) from age 55 to 105, accounting for competing risk of death, and to examine differences by sex and race.

Methods

We analyzed data from five harmonized longitudinal cohort studies at the Rush Alzheimer's Disease Center, including 4611 community dwelling older adults for lifetime dementia risk estimation and 3915 for lifetime MCI risk estimation. Incident dementia and MCI were identified through annual clinical evaluations. Nonparametric cumulative incidence function curves estimated lifetime risk, adjusting for competing risk of death and left truncation. Additional analyses assessed lifetime risk from index ages 55, 65, 75, and 85 and examined differences by sex and race.

SUBMITTER: Du L 

PROVIDER: S-EPMC12424864 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature