Gene-environment interaction analysis in atopic eczema: evidence from large population datasets and modelling <i>in vitro</i>.

ABSTRACT:

Background

Environmental factors play a role in the pathogenesis of complex traits including atopic eczema (AE) and a greater understanding of gene-environment interactions (G*E) is needed to define pathomechanisms for disease prevention. We analysed data from 16 European studies to test for interaction between the 24 most significant AE-associated loci identified from genome-wide association studies and 18 early-life environmental factors. We tested for replication using a further 10 studies and in vitro modelling to independently assess findings.

Results

The discovery analysis showed suggestive evidence for interaction (p<0.05) between 7 environmental factors (antibiotic use, cat ownership, dog ownership, breastfeeding, elder sibling, smoking and washing practices)

SUBMITTER: Standl M 

PROVIDER: S-EPMC12424891 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature