Organization of Brainwide Inputs to Discrete Lateral Septum Projection Populations.

ABSTRACT: The lateral septum (LS) is anatomically positioned to play a critical role in directing information from the hippocampus and cortex to downstream subcortical structures, such as the hypothalamus. Early anatomical tracing studies investigated the organization of hippocampal inputs to the LS and its hypothalamic outputs to begin to understand how its structure might relate to its function. These studies also characterized the cellular anatomy of the LS and the organization of molecular markers within it. However, little is known about the organization of nonhypothalamic projection populations within the LS and what types of input these different projection populations receive. We used retrograde tracing to determine the organization of LS projections to six brain regions that mediate various

SUBMITTER: Isaac J 

PROVIDER: S-EPMC12424961 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature