Zolpidem restores sleep and slows Alzheimer's progression in a mouse model.

ABSTRACT:

Introduction

Deficits in Non-Rapid Eye Movement (NREM) sleep facilitate Alzheimer's disease (AD) progression. Enhancing GABAergic signaling can restore sleep. Unbiased computational analysis identified zolpidem as high-affinity GABA receptor modulator facilitating chloride transport that could slow AD.

Methods

Zolpidem's effects on sleep and Alzheimer's progression were evaluated in young APP/PS1 mice. Sleep was monitored with EEG/EMG telemetry. Widefield imaging with voltage-sensitive dyes was used to track sleep-dependent brain rhythms. Multiphoton microscopy allowed assessments of amyloid plaque load and basal neuronal calcium levels. Behavioral assays were used to measure memory and cognitive function.

Results

Zolpidem restored NREM sleep and rescued sleep-depende

SUBMITTER: Yu L 

PROVIDER: S-EPMC12425003 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature