Valvular Heart Disease Associations with Cardiac Biomarkers Using AI-guided Echocardiography: the RURAL Cohort Study.

ABSTRACT:

Background

Few studies have evaluated the prevalence or severity of mitral valve prolapse (MVP) and other valvular heart disease (VHD) in the rural US South, where strategies for early detection are crucial for risk stratification and prevention.

Objectives

We assessed the prevalence of MVP and other VHD in a rural US South cohort and examined associations with cardiovascular disease (CVD) risk. We also evaluated relationships between MVP severity, high-sensitivity cardiac troponin T (hsTnT), and N-terminal pro-B-type natriuretic peptide (NTproBNP).

Methods

We conducted a cross-sectional analysis from the Risk Underlying Rural Areas Longitudinal (RURAL) study. Logistic regression assessed associations between participant characteristics and MVP, other VHD, or both. We

SUBMITTER: Alexopoulos E 

PROVIDER: S-EPMC12425031 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature