An explorative analysis of plasma biomarkers associated with cerebral amyloid angiopathy.

ABSTRACT:

Background

Cerebral amyloid angiopathy (CAA) remains diagnostically challenging, particularly in asymptomatic individuals. While CAA often co-exists with Alzheimer's disease (AD), it may even have a direct impact on AD pathophysiology and the cognitive decline within the clinical course of AD. While fluid biomarkers are well-established for AD pathology, reliable markers to improve the characterization of CAA are lacking.

Methods

We analyzed two subsets of participants from the Alzheimer's Disease Neuroimaging Initiative: one with available T2*-weighted gradient echo magnetic resonance imaging (MRI) (n=21) and another with postmortem neuropathological data (n=24), all with available plasma biomarkers from a 145-analyte multiplex immunoassay panel. We defined CAA as two or mo

SUBMITTER: Ersozlu E 

PROVIDER: S-EPMC12425035 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature