Genetic determinants of micronutrient levels and their causal impact on osteonecrosis of the femoral head: A 2-sample Mendelian randomization study.

ABSTRACT: Osteonecrosis of the femoral head (ONFH) is a debilitating condition with unclear pathophysiology. Micronutrients are implicated in bone health, but their causal relationship with ONFH remains uncertain. This study aims to investigate the potential causal relationship between circulating levels of 15 micronutrients and the risk of ONFH using a 2-sample Mendelian randomization (MR) approach. The objective was to determine whether circulating levels of specific micronutrients (copper, calcium, carotene, folate, iron, magnesium, potassium, selenium, vitamin A, vitamin B12, vitamin B6, vitamin C, vitamin D, vitamin E, and zinc) have a causal impact on the risk of ONFH. This study employed a 2-sample MR approach using summary-level data from 15 genome-wide association studies (GWAS) focused on

SUBMITTER: Hu H 

PROVIDER: S-EPMC12425091 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature