Factors associated with aspirin resistance in diabetic patients: A metabolic and inflammatory profile analysis.

ABSTRACT:

Background

Diabetes mellitus (DM) is strongly linked to both first-time and recurrent atherosclerotic thrombotic events. Although aspirin (ASA) is commonly used to prevent cardiovascular diseases, studies have shown that ASA does not significantly reduce the risk of cardiovascular events in DM patients. This inconsistency highlights the need for further research into the underlying mechanisms of ASA resistance. Therefore, this study investigates the factors associated with aspirin resistance in DM patients, aiming to offer insights for improving cardiovascular disease prevention in this group. This study specifically investigated biochemical aspirin resistance, defined as inadequate suppression of thromboxane biosynthesis.

Methods

This prospective case-control study enrolled

SUBMITTER: Chen B 

PROVIDER: S-EPMC12425219 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature