Pdgfab/Pdgfra-mediated chemoattraction guides the migration of sclerotome-derived fibroblast precursors in zebrafish.

ABSTRACT: In vertebrates, the sclerotome is a transient embryonic structure that gives rise to various tissue support cells, including fibroblasts. However, how fibroblast precursors are guided to diverse tissues remain poorly understood. Using zebrafish, our lab has previously shown that sclerotome-derived cells undergo extensive migration to generate distinct fibroblast subtypes, including tenocytes along the myotendinous junction and fin mesenchymal cells in the fin fold. The pan-fibroblast gene platelet-derived growth factor receptor a (pdgfra), which has been implicated in cell migration across various contexts, is specifically expressed in the sclerotome and its descendants. Loss of functional Pdgfra in a pdgfra gene-trap mutant results in severe defects in the migration of sclerotome-derived

SUBMITTER: Mendez-Olivos EE 

PROVIDER: S-EPMC12425304 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature