Associations of high-risk drug patterns with mortality among community-dwelling older adults: A 23-year prospective cohort study.

ABSTRACT:

Background

Data on drug safety in multimorbid older-adults are limited, as clinical trials often apply upper age limits and focus on individual drugs or specific combinations. We aimed to explore high-risk drug patterns in community-dwelling older-adults, and their associations with long-term mortality.

Methods

We included 1,048 participants from a longitudinal population-based cohort, all taking at least one medication. Participants were examined in 1999-2007 and followed for mortality through March 2022. Individuals with similar profiles of high-risk drugs, identified using Beers criteria as potentially inappropriate for most older adults or requiring caution, were grouped using agglomerative hierarchical clustering. Cox and competing-risk regressions were used to examine

SUBMITTER: Orenstein L 

PROVIDER: S-EPMC12425332 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature