Proto-SLIPS: Slippery Liquid-Infused Surfaces that Release Highly Water-Soluble Agents.

ABSTRACT: Slippery liquid-infused porous surfaces (or "SLIPS") can prevent bacterial surface fouling, but they do not inherently possess the means to kill bacteria or reduce cell loads in surrounding media. Past reports show that the infused liquids in these materials can be leveraged to load and release antimicrobial agents, but these approaches are generally limited to the use of hydrophobic agents that are soluble in the infused oily phases. Here, we report the design of so-called "proto-SLIPS" that address this limitation and permit the release of highly water-soluble (or oil-insoluble) agents. This approach involves the physical patterning of small, dried spots of hydrophilic drugs on the surfaces of hydrophobic porous materials and leads to analogs of conventional SLIPS that contain drug-patte

SUBMITTER: Wang F 

PROVIDER: S-EPMC12425458 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature