Xcr1⁺ type 1 conventional dendritic cells are essential mediators for atherosclerosis progression.

ABSTRACT: Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however, the cellular and molecular mechanisms that trigger the inflammatory response in atherosclerotic plaques remain far from being fully understood. Xcr1⁺ cDC1 cells are newly identified antigen-presenting cells in activating immune cells. However, the role of cDC1 cells in atherosclerosis development remains highly controversial. We first confirmed the presence of cDC1 within human atherosclerotic plaques and discovered a significant association between the increasing cDC1 numbers and atherosclerosis progression in mice. Subsequently, we established Xcr1^Cre-Gf

SUBMITTER: Li T 

PROVIDER: S-EPMC12425476 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature