Effect of tegoprazan on temporal variability of platelet reactivity in patients treated with clopidogrel after coronary stenting.

ABSTRACT:

Background/aims

Data on the interactions between clopidogrel and tegoprazan are limited. We compared the effects of tegoprazan and proton-pump inhibitors (PPIs) on platelet reactivity.

Methods

Using database data from March 2020 to January 2023, we retrospectively evaluated 262 patients who were taking either tegoprazan (n = 107) or PPIs (n = 155) combined with dual antiplatelet therapy, including aspirin and clopidogrel, after percutaneous coronary intervention. Platelet reactivity was assessed using VerifyNow P2Y12 assays.

Results

Platelet reaction unit (PRU) values at 3 (157 ± 8 vs. 162 ± 6, p = 0.659), 6 (167 ± 9 vs. 158 ± 7, p = 0.370), and 12 months (155 ± 10 vs. 164 ± 7, p = 0.448) were similar between groups. The prevalence of high on-treatment platelet reacti

SUBMITTER: Lee OH 

PROVIDER: S-EPMC12425681 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature