Impact of guideline-directed medical therapy on the cardiac or non-cardiac death in acute myocardial infarction.

ABSTRACT:

Background/aims

While the clinical effectiveness of guideline-directed medical therapy (GDMT) is well established in patients with acute myocardial infarction (AMI), its specific impact on cause-specific mortality remains unclear. This study aimed to investigate the impact of GDMT on both cardiac and non-cardiac mortality in AMI patients.

Methods

Data of the KAMIR-NIH, a multicenter prospective registry of AMI in Korea between 2011 and 2015, were included. The competing risks of cardiac and non-cardiac death in patients who received GDMT were compared with those who did not, using a multivariable-adjusted cumulative incidence analysis of propensity score-matched patients. Primary endpoint of interest was 3-year cardiac and non-cardiac mortality.

Results

Of the 12,815

SUBMITTER: Choi JH 

PROVIDER: S-EPMC12425685 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature