Metabolic adaptation fluctuates with different prediction equations: a secondary analysis based on a weight-loss clinical trial.

ABSTRACT:

Objective

Metabolic adaption (MA) might be of clinical relevance in weight loss management. However, it is unclear whether resting metabolic rate (RMR) reduction in weight loss reflects true MA or fat free mass (FFM) loss.

Methods

We re-analyzed the data based on a weight loss trial of 131 patients (aged 33.3 ± 6.7 years) with overweight/obesity. Anthropometric data, body composition, daily physical activity, sleep hour and dietary intake were collected for every 4 weeks (baseline, week 4, 8, 12, and 16). The linear mixed model was used to evaluate the absolute change in RMR and adjusted RMR [aRMR = RMR (kcal) divided by FFM (kg)] with two different equations (Katch-McArdle-determined vs. BIA-determined) for every 4 weeks after adjustment of age, sex, daily physical activity

SUBMITTER: Tang M 

PROVIDER: S-EPMC12425712 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature