Global, regional, and national burdens of cirrhosis in childhood and adolescence during 2000 to 2021: an age-period-cohort analysis.

ABSTRACT:

Background

Cirrhosis is a major cause of morbidity and mortality worldwide, but data on the cirrhosis burden and trends in children and adolescents are sparse.

Methods

Data on cirrhosis during 2000-2021, including global-, regional, and national-level numbers of cases, incidence, and prevalence, were collected by the GBD 2021 database. Trends across age groups, periods, and birth cohorts were analysed using the age-period-cohort (APC) model; epidemiological trajectories were predicted using the Bayesian APC (BAPC) model.

Results

From 2000 to 2021, cirrhosis incidence decreased in the 5-9 and 10-14-year age groups but increased in the 15-19 and 20-24-year age groups. In the 15-19- and 20-24-year age groups, the respective proportion of cirrhosis due to hepatitis B decr

SUBMITTER: Yang XQ 

PROVIDER: S-EPMC12425971 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature