The nonlinear association between the triglyceride glucose-waist-to-height ratio index and cardiovascular disease among middle-aged and older adults in China with cardiovascular-kidney-metabolic syndrome stages 0-3.

ABSTRACT:

Background

Cardiovascular disease (CVD) poses a critical challenge to global public health, especially in individuals with Cardiovascular-Kidney-Metabolic (CKM) syndrome. The association between the triglyceride glucose-waist-to-height ratio index (TyG-WHtR) and CVD among middle-aged and older Chinese adults with CKM stages 0-3 is not well understood.

Methods

Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative longitudinal study of individuals aged 45 years and older. Cox proportional hazards models were constructed to evaluate the association between TyG-WHtR and CVD risk. Subgroup analyses were conducted among different groups to evaluate consistency of findings and explore potential interactions. Restricted cubi

SUBMITTER: Huang C 

PROVIDER: S-EPMC12426055 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature