Foot-and-mouth disease virus vaccine with VP1 G-H loop substitution of the Cathay strain broadens antigen spectrum.

ABSTRACT: Recently, serotype O foot-and-mouth disease viruses (FMDVs) belonging to four lineages (O/ME-SA/PanAsia, O/ME-SA/Ind2001, O/SEA/Mya-98, and O/Cathay) co-circulate in China, and the emergence of new variant viruses belonging to the Cathay lineage renders the existing vaccines less effective, which poses a serious threat to the livestock industries. The surface-exposed G-H loop of the VP1 structural protein of FMDV plays an important role in inducing neutralizing antibodies, generation of antigenic variants, and virus attachment. Here, we generated three recombinant FMDVs in which the G-H loops have been substituted with the corresponding sequences from the circulating strains of the PanAsia, Mya-98, and Cathay lineages based on an infectious cDNA clone of a chimeric FMDV, which carries amin

SUBMITTER: Zha J 

PROVIDER: S-EPMC12426072 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature