Efficacy and safety of respiratory strength and endurance training in patients with myotonic dystrophy type 1 (DM1): a randomized controlled trial.

ABSTRACT:

Background

Myotonic dystrophy type 1 (DM1) is a multisystem disorder characterized by progressive muscle weakness, including the respiratory muscles, which often leads to ventilatory insufficiency. Despite its clinical relevance, high-quality controlled data on the effects of respiratory muscle training in DM1 are limited.

Objective

To evaluate the safety and effectiveness of long-term, home-based inspiratory muscle training (IMT) using a commercially available inspiratory training device in genetically confirmed DM1 patients.

Methods

This was a single-center, randomized controlled trial involving three parallel groups: inspiratory strength training, inspiratory endurance training, and a control group without training. Patients were followed over 9 months. The primary

SUBMITTER: Wenninger S 

PROVIDER: S-EPMC12426088 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature