Global, regional, and national burden of early-onset ischemic heart disease: trends and projections among adults aged 15-44 years from 1990 to 2046.

ABSTRACT:

Background

Ischemic heart disease (IHD) among young adults represents an emerging global health concern, yet comprehensive epidemiological assessments remain limited. This study aimed to quantify the global burden of early-onset IHD and project future trends through 2046.

Methods

We analyzed data from the Global Burden of Disease (GBD) 2021 study, examining IHD burden among adults aged 15-44 years across 204 countries and territories from 1990 to 2021. Age-standardized rates were calculated using WHO standard population weights. Temporal trends were assessed using estimated annual percentage change (EAPC) methods. Age-Period-Cohort models were employed to project burden through 2046. DALYs were disaggregated into Years Lived with Disability (YLDs) and Years of Life Lost (YLL

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12426116 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature