Dissemination of OXA-23 carbapenemase-producing <i>Proteus mirabilis</i> and <i>Escherichia coli</i> is driven by transposon-carrying lineages in the UK.

ABSTRACT: Carbapenem-resistant Enterobacterales are a significant threat to global public health. Here, we characterize bla _OXA-23-positive Proteus mirabilis (n=8) and Escherichia coli (n=3) isolates from human clinical samples collected between 2021 and 2024 in the UK. Whole-genome sequencing (WGS) was used to generate data, and a phylogenetic tree inferred from SNPs filtered for recombination was constructed to assess the genomic relatedness among the isolates. To provide an international context, we included publicly available genomes. Short-read mapping to a reference genome enabled reconstruction of the genomic neighbourhood around bla _OXA-23. Minimum inhibitory concentration (MIC) determination was performed using broth mic

SUBMITTER: Zamudio R 

PROVIDER: S-EPMC12426204 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature