3D nanoprinting of embryo microinjection needles with anti-clogging features.

ABSTRACT: Wide-ranging biomedical applications spanning both research and clinical settings rely on microinjection protocols that involve using a long, hollow microneedle to deliver foreign substances directly into biological targets, such as embryos. Unfortunately, conventional microneedles are prone to clogging-e.g., cytoplasmic material from an embryo becoming lodged inside the needle tip during penetration, thereby obstructing delivery-motivating researchers to use top-down microfabrication techniques to modify needle tips and reduce such failure modes. Recent advancements for the submicron-scale additive manufacturing approach, "Two-Photon Direct Laser Writing (DLW)", offer a new, bottom-up pathway for re-architecting microneedle tips to address clogging susceptibility via geometric means. Here

SUBMITTER: Sarker S 

PROVIDER: S-EPMC12426209 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature