Children With Celiac Disease Have a Higher Degree of Activated or Exhausted CD4⁺ and CD8⁺ T Cells Compared to Healthy References.

ABSTRACT: Type 1 diabetes (T1D) and celiac disease (CeD) are two chronic autoimmune disorders commonly diagnosed during childhood. In this exploratory study we performed flow cytometric immunophenotyping of various immune cell populations in peripheral blood from children with T1D, CeD, a T1D and CeD comorbidity, and from age-matched healthy references (controls). With extensive flow cytometry panels covering subpopulations of both CD4⁺ and CD8⁺ T cells, as well as monocytes and NK cells, our main finding is a tendency towards a higher degree of activated/exhausted T cells in children with a sole diagnosis of CeD compared with healthy references. This was seen through a higher fraction of CD4⁺ T cells positive for PD-1, CCR5 and CCR10, as well as a higher fraction of

SUBMITTER: Tompa A 

PROVIDER: S-EPMC12426357 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature