Early- Versus Newer-Generation Transcatheter Mitral Valve Edge-to-Edge Repair Systems: Insights From the OCEAN-Mitral Registry.

ABSTRACT:

Background

Comparative data on early- (G2) vs newer-generation (G4) MitraClip transcatheter edge-to-edge repair (TEER) systems remain limited.

Objectives

The authors compared procedural and clinical outcomes of both devices in patients with degenerative mitral regurgitation (DMR) or functional mitral regurgitation (FMR).

Methods

Using the OCEAN (Optimized Catheter Valvular Intervention)-Mitral registry, 3,738 patients undergoing TEER with either G2 (n = 1,481) or G4 (n = 2,257) MitraClips were analyzed. Outcomes included procedural metrics, echocardiographic parameters, and clinical events.

Results

Despite being older (P = 0.010) and higher-risk (EuroSCORE [European System for Cardiac Operative Risk Evaluation] II: P = 0.002), the newer-generation group achieve

SUBMITTER: Okuno T 

PROVIDER: S-EPMC12426677 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature