The Space-Time Organisation of Sleep Slow Oscillations as Potential Biomarker for Hypersomnolence.

ABSTRACT: Research suggests that the spatial profile of slow wave activity (SWA) could be altered in hypersomnolence. Slow oscillations (SOs; 0.5-1.5 Hz), single waveform events contributing to SWA, can be labelled as Global, Frontal, or Local depending on their presentation on the scalp. We showed that SO space-time types differentiate in their amplitudes, coordination with sleep spindles, and propagation patterns. This study applies our data-driven analysis to the nocturnal sleep of adults with and without hypersomnolence and major depressive disorder (MDD) to explore the potential relevance of SO space-time patterns as hypersomnolence signatures in the sleep EEG. We leverage an existing dataset of nocturnal polysomnography with high-density EEG in 83 adults, organised in four groups depending on

SUBMITTER: Alipour M 

PROVIDER: S-EPMC12426695 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature