SPOCK2 promotes the invasion and migration of ovarian cancer cells through FAK signaling pathway.

ABSTRACT:

Objective

Ovarian cancer is one of the most prevalent malignancies worldwide, with the highest mortality rate among gynecological cancers. This study aims to investigate the molecular mechanisms of SPOCK2 in ovarian cancer progression and metastasis and evaluate its potential as a therapeutic target.

Methods

The expression levels of SPOCK2 in ovarian cancer tissues and normal tissues were analyzed using data from The Cancer Genome Atlas (TCGA) and immunohistochemistry experiments. Functional assays, including epithelial-mesenchymal transition (EMT), invasion, and migration assays, were performed in high-grade serous ovarian cancer (HGSOC) cells to explore the role of SPOCK2. The interaction between SPOCK2 and ITGA3 and the subsequent activation of focal adhesion kinase (FAK)

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12426747 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature