PLIN2: a potential prognostic markers of early-stage atypical endometrial hyperplasia.

ABSTRACT:

Objective

In the background of endometrial hyperplasia triggered by obesity and estrogen, could the perilipin 2 (PLIN2) serve as a possible prognostic marker for early atypical endometrial hyperplasia (AEH)?

Methods

A retrospective study examined blood lipid levels in endometrial cancer (EC) or AEH patients. An AEH mice model was established administrating with estradiol and/or high-fat (HF) diet. Hematoxylin and eosin staining were employed to assess pathological changes in the endometrium. Immunohistochemical staining were employed to evaluate the expression of adipose metabolism and endometrial hyperplasia proteins. The Cell Counting Kit-8 assay, cell colony-forming assays, and western blotting were utilized to verify the impact of oleic acid (OA) on HEC-1A cells.

Resu

SUBMITTER: Lian C 

PROVIDER: S-EPMC12426750 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature